Columbia University | Department of Neurology
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 Ali Naini, Ph.D. Director, Laboratories of Metabolic and Mitochondrial Diseases, Departments of Pathology & Cell Biology and Neurology Address Board Certifications |
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Affiliations: » The Merritt Center Laboratory of Molecular Neurogenetics Research Summary Dr. Ali Naini is a Senior Research Scientist and Director of Laboratory of Molecular Neurogenetics in the Department of Neurology and a member of Houston Merritt Center for Clinical Research. Dr. Naini's research interests include molecular pathogenesis of neurodegenerative diseases and primary CoQ defeiciency. In collaboration with Drs. Hiroshi Mitsumoto, Michio Hirano, and Serge Przedborski, Dr. Naini studies patients affected with amyotrophic lateral sclerosis (Lou Gehrig's Disease) harboring mutations in their Cu/Zn superoxide dismutase gene. In collaboration with Drs. Savatore DiMauro, and Michio Hirano, he also studies patients with mitochondrial encephalomyopathy due to primary CoQ deficiency. Dr. Naini is board certified clinical biochemist and molecular geneticist. He received his graduate training at London University and University of Surrey in the United Kingdom. Dr. Naini joined Neuromuscular group at Houston Merritt Center in 1997 as the director of the Laboratory of Molecular Neurogenetics and Mitochondrial Diseases. Dr. Naini is a regular reviewer of several international journals and is author and co-author of numerous publications related to the pathogenesis and molecular aspects of neurological diseases. Selected Publications 1. Naini, A., Toscano, A., Musumeci, O., Vissing, J., Akman, H.O., and DiMauro, S. (2009). Muscle phosphoglycerate mutase deficiency revisited. Arch Neurol 66:394-398. 2. Mehrazin, M., Shanske, S., Kaufmann, P., Wei, Y., Coku, J., Engelstad, K., Naini, A., De Vivo, D.C., and Dimauro, S. (2009). Longitudinal changes of mtDNA A3243G mutation load and level of functioning in MELAS. Am J Med Genet A. 3. Coku, J., Shanske, S., Mehrazin, M., Tanji, K., Naini, A., Emmanuele, V., Patterson, M., Hirano, M., and Dimauro, S. (2009). Slowly progressive encephalopathy with hearing loss due to a mutation in the mtDNA tRNA(Leu(CUN)) gene. J Neurol Sci. 4. Tanji, K., Kaufmann, P., Naini, A., Lu, J., Parsons, T.C., Wang, D., Willey, J.Z., Shanske, S., Hirano, M., Bonilla, E., et al. (2008). A novel tRNA(Val) mitochondrial DNA mutation causing MELAS. J Neurol Sci. 5. Shanske, S., Coku, J., Lu, J., Ganesh, J., Krishna, S., Tanji, K., Bonilla, E., Naini, A., Hirano, M., and Dimauro, S. (2008). The G13513A Mutation in the ND5 Gene of Mitochondrial DNA as a Common Cause of MELAS or Leigh Syndrome: Evidence From 12 Cases. Arch Neurol 65:368-372. 6. Quinzii, C.M., Lopez, L.C., Von-Moltke, J., Naini, A., Krishna, S., Schuelke, M., Salviati, L., Navas, P., DiMauro, S., and Hirano, M. (2008). Respiratory chain dysfunction and oxidative stress correlate with severity of primary CoQ10 deficiency. FASEB J 22:1874-1885. 7. Quinzii, C.M., LC, L.P., Naini, A., Dimauro, S., and Hirano, M. (2008). Human CoQ_{10} deficiencies. Biofactors 32:113-118. 8. Hirano, M., Angelini, C., Montagna, P., Hays, A.P., Tanji, K., Mitsumoto, H., Gordon, P.H., Naini, A., Dimauro, S., and Rowland, L.P. (2008). Amyotrophic lateral sclerosis with ragged-red fibers. Arch Neurol 65:403-406. 9. Bornstein, B., Area, E., Flanigan, K.M., Ganesh, J., Jayakar, P., Swoboda, K.J., Coku, J., Naini, A., Shanske, S., Tanji, K., et al. (2008). Mitochondrial DNA depletion syndrome due to mutations in the RRM2B gene. Neuromuscul Disord 18:453-459. 10. Naini, A., and Shanske, S. 2007. Detection of Mutations in mtDNA. Methods Cell Biol 80:437-463. Book chapters Naini A., Shanske S. Detection of mutation in mtDNA. In L Pon and E Schon (ed). Mitochondria. New York: Academic Press, (2007); 437-463. DiMauro S, Shanske S, Naini A., Krishna, S. In T.E. Bertorini (ed). Clinical Evaluation and Diagnostic tests for Neuromuscular Disorders. New York: Butterworth Heinemann:, (2002);535-564. » Publications in NLM's PubMed |
Updated April 9, 2010 • Comments