RESPIRATORY CHAIN ENZYMES

Because the 13 proteins encoded by mtDNA are all components of respiratory chain complexes, any deleterious mutation or severe depletion of mtDNA results in impaired function of this vital terminal pathway of mitochondrial metabolism, with decreased ATP generation, excessive production of reactive oxygen radicals (ROS), or both situations.

Specimen:

Biopsy should be snap frozen immediately in liquid nitrogen and shipped on dry ice. The biopsy should be approximately 0.1 cm in diameter and 0.5 cm in length; approximate weight should be 100-200 mg.

Shipping:

Muscle: should be sent frozen on dry ice and by overnight carrier to the address below.

Dr. Ali Naini

Laboratory of Melocular Neurogenetics

Columbia University Medical Center
Department of Pathology
630 West 168th Street, VC15th Floor, Room 208
New York, NY 10032

Phone: 212-305-3947
FAX: 212-305-3986

CPT Codes:

82657 times 6, and 83912

Price:

$550.00 6-enzyme battery